https://pubmed.ncbi.nlm.nih.gov/9506567/
Park JH, Phothimat P, Oates CT, Hernanz-Schulman M, Olsen NJ.
Use of P-31 magnetic resonance spectroscopy to detect metabolic
abnormalities in muscles of patients with fibromyalgia. Arthritis
Rheum 1998;41(3):406-13.
https://pubmed.ncbi.nlm.nih.gov/20603699/
Gerdle B, Söderberg K, Salvador Puigvert L, Rosendal L, Larsson
B. Increased interstitial concentrations of pyruvate and lactate in
the trapezius muscle of patients with fibromyalgia: a microdialysis
study. J Rehabil Med 2010;42(7):679-87.
https://pubmed.ncbi.nlm.nih.gov/9225876/
Volkmann H, Nørregaard J, Jacobsen S, Danneskiold-Samsøe B,
Knoke G, Nehrdich D. Double-blind, placebo-controlled cross-over
study of intravenous S-adenosyl-L-methionine in patients with
fibromyalgia. Scand J Rheumatol 1997;26(3):206-11.
https://www.ncbi.nlm.nih.gov/pubmed/17109576
Teitelbaum JE, Johnson C, St Cyr J. The use of D-ribose in
chronic fatigue syndrome and fibromyalgia: a pilot study. J Altern
Complement Med 2006;12(9):857-62.
https://pubmed.ncbi.nlm.nih.gov/33642123/
Teng HW, Tani J, Chang TS, Chen HJ, Lin YC, Lin CS, Sung JY.
Altered sensory nerve excitability in fibromyalgia. J Formos Med
Assoc 2021;120(8):1611-1619.
https://pubmed.ncbi.nlm.nih.gov/33570701/
Lozano-Plata LI, Vega-Morales D, Esquivel-Valerio JA,
Garza-Elizondo MA, Galarza-Delgado DA, Silva-Luna K, Serna-Peña G,
Sifuentes-Ramírez J, Garza-Guerra AJ, Díaz-Niño de Rivera R. Efficacy
and safety of weekly vitamin D
3 in patients with fibromyalgia: 12-week, double-blind,
randomized, controlled placebo trial. Clin Rheumatol
2021;40(8):3257-3264.
https://pubmed.ncbi.nlm.nih.gov/33142767/
Gerdle B, Ghafouri B, Lund E, Bengtsson A, Lundberg P,
Ettinger-Veenstra HV, Leinhard OD, Forsgren MF. Evidence of
Mitochondrial Dysfunction in Fibromyalgia: Deviating Muscle Energy
Metabolism Detected Using Microdialysis and Magnetic Resonance. J
Clin Med 2020;9(11):.
https://pubmed.ncbi.nlm.nih.gov/33576773/
"OMahony LF", Srivastava A, Mehta P, Ciurtin C. Is fibromyalgia
associated with a unique cytokine profile? A systematic review and
meta-analysis. Rheumatology (Oxford) 2021;60(6):2602-2614.
https://www.ncbi.nlm.nih.gov/pubmed/25651705
Toker A, Kucuksen S, Kucuk A, Cicekler H. Serum
ischemia-modified albumin and malondialdehyde levels and superoxide
dismutase activity in patients with fibromyalgia. Clin Lab
2014;60(10):1609-15.
https://pubmed.ncbi.nlm.nih.gov/32727475/
Holden S, Maksoud R, Eaton-Fitch N, Cabanas H, Staines D,
Marshall-Gradisnik S. A systematic review of mitochondrial
abnormalities in myalgic encephalomyelitis/chronic fatigue
syndrome/systemic exertion intolerance disease. J Transl Med
2020;18(1):290.
https://pubmed.ncbi.nlm.nih.gov/30523152/
Hackshaw KV, Aykas DP, Sigurdson GT, Plans M, Madiai F, Yu L,
Buffington CAT, Giusti MM, Rodriguez-Saona L. Metabolic
fingerprinting for diagnosis of fibromyalgia and other rheumatologic
disorders. J Biol Chem 2019;294(7):2555-2568.
https://pubmed.ncbi.nlm.nih.gov/33033448/
Shukla V, Kumar DS, Ali MA, Agarwal S, Khandpur S. Nitric
oxide, lipid peroxidation products, and antioxidants in primary
fibromyalgia and correlation with disease severity. J Med Biochem
2020;39(2):165-170.
https://pubmed.ncbi.nlm.nih.gov/33583408/
Zetterman T, Markkula R, Partanen JV, Miettinen T, Estlander
AM, Kalso E. Muscle activity and acute stress in fibromyalgia. BMC
Musculoskelet Disord 2021;22(1):183.
https://pubmed.ncbi.nlm.nih.gov/33782445/
Lupo GFD, Rocchetti G, Lucini L, Lorusso L, Manara E, Bertelli
M, Puglisi E, Capelli E. Potential role of microbiome in Chronic
Fatigue Syndrome/Myalgic Encephalomyelits (CFS/ME). Sci Rep
2021;11(1):7043.
https://pubmed.ncbi.nlm.nih.gov/33664680/
Jackson D, Singh S, Zhang-James Y, Faraone S, Johnson B. The
Effects of Low Dose Naltrexone on Opioid Induced Hyperalgesia and
Fibromyalgia. Front Psychiatry 2021;12():593842.
https://pubmed.ncbi.nlm.nih.gov/33260218/
Hulens M, Bruyninckx F, Dankaerts W, Rasschaert R, De Mulder P,
Stalmans I, Vansant G, Bervoets C. High Prevalence of Perineural
Cysts in Patients with Fibromyalgia and Chronic Fatigue Syndrome.
Pain Med 2021;22(4):883-890.
https://pubmed.ncbi.nlm.nih.gov/32975538/
Slade GD, Greenspan JD, Fillingim RB, Maixner W, Sharma S,
Ohrbach R. Overlap of Five Chronic Pain Conditions: Temporomandibular
Disorders, Headache, Back Pain, Irritable Bowel Syndrome, and
Fibromyalgia. J Oral Facial Pain Headache
2020;34():s15-s28.
https://pubmed.ncbi.nlm.nih.gov/1925418/
Jacobsen S, Danneskiold-Samsøe B, Andersen RB. Oral
S-adenosylmethionine in primary fibromyalgia. Double-blind clinical
evaluation. Scand J Rheumatol 1991;20(4):294-302.
https://www.ncbi.nlm.nih.gov/pubmed/20666654
Nazıroğlu M, Akkuş S, Soyupek F, Yalman K, Çelik Ö, Eriş S,
Uslusoy GA. Vitamins C and E treatment combined with exercise
modulates oxidative stress markers in blood of patients with
fibromyalgia: a controlled clinical pilot study. Stress
2010;13(6):498-505.
https://pubmed.ncbi.nlm.nih.gov/33645659/
Reyes Del Paso GA, Contreras-Merino AM, de la Coba P, Duschek
S. The cardiac, vasomotor, and myocardial branches of the baroreflex
in fibromyalgia: Associations with pain, affective impairments, sleep
problems, and fatigue. Psychophysiology 2021;58(5):e13800.
https://pubmed.ncbi.nlm.nih.gov/33740353/
Pappolla MA, Manchikanti L, Candido KD, Grieg N, Seffinger M,
Ahmed F, Fang X, Andersen C, Trescot AM. Insulin Resistance is
Associated with Central Pain in Patients with Fibromyalgia. Pain
Physician 2021;24(2):175-184.
https://pubmed.ncbi.nlm.nih.gov/32773602/
Gilron I, Robb S, Tu D, Holden R, Towheed T, Ziegler D, Wang L,
Milev R, Gray C. Double-blind, randomized, placebo-controlled
crossover trial of alpha-lipoic acid for the treatment of
fibromyalgia pain: the IMPALA trial. Pain
2021;162(2):561-568.
https://pubmed.ncbi.nlm.nih.gov/33556139/
Seo S, Jung YH, Lee D, Lee WJ, Jang JH, Lee JY, Choi SH, Moon
JY, Lee JS, Cheon GJ, Kang DH. Abnormal neuroinflammation in
fibromyalgia and CRPS using [11C]-(R)-PK11195 PET. PLoS One
2021;16(2):e0246152.
https://www.ncbi.nlm.nih.gov/pubmed/16805968
Altindag O, Celik H. Total antioxidant capacity and the
severity of the pain in patients with fibromyalgia. Redox Rep
2006;11(3):131-5.
https://pubmed.ncbi.nlm.nih.gov/23887335/
Gerdle B, Larsson B, Forsberg F, Ghafouri N, Karlsson L,
Stensson N, Ghafouri B. Chronic widespread pain: increased glutamate
and lactate concentrations in the trapezius muscle and plasma. Clin J
Pain 2014;30(5):409-20.
https://pubmed.ncbi.nlm.nih.gov/33409721/
Martínez-Lavín M. Dorsal root ganglia: fibromyalgia pain
factory? Clin Rheumatol 2021;40(2):783-787.
https://pubmed.ncbi.nlm.nih.gov/33003107/
Merriwether EN, Agalave NM, Dailey DL, Rakel BA, Kolker SJ,
Lenert ME, Spagnola WH, Lu Y, Geasland KM, Allen LH, Burton MD, Sluka
KA. IL-5 mediates monocyte phenotype and pain outcomes in
fibromyalgia. Pain 2021;162(5):1468-1482.
https://pubmed.ncbi.nlm.nih.gov/32677448/
Menzies V, Starkweather A, Yao Y, Kelly DL, Garrett TJ, Yang G,
Booker S, Swift-Scanlan T, Mahmud I, Lyon DE. Exploring Associations
Between Metabolites and Symptoms of Fatigue, Depression and Pain in
Women With Fibromyalgia. Biol Res Nurs 2021;23(1):119-126.
https://pubmed.ncbi.nlm.nih.gov/33084477/
Sauch Valmaña G, Vidal-Alaball J, Poch PR, Peña JM, Panadés
Zafra R, Cantero Gómez FX, Ruíz Comellas A, Barranco Reixachs D.
Effects of a Physical Exercise Program on Patients Affected with
Fibromyalgia. J Prim Care Community Health
2020;11():2150132720965071.
https://www.ncbi.nlm.nih.gov/pubmed/20035260
Maes M, Mihaylova I, Kubera M, Uytterhoeven M, Vrydags N,
Bosmans E. Increased 8-hydroxy-deoxyguanosine, a marker of oxidative
damage to DNA, in major depression and myalgic encephalomyelitis /
chronic fatigue syndrome. Neuro Endocrinol Lett
2009;30(6):715-22.
https://pubmed.ncbi.nlm.nih.gov/33882940/
Wirth KJ, Scheibenbogen C. Pathophysiology of skeletal muscle
disturbances in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
(ME/CFS). J Transl Med 2021;19(1):162.
https://pubmed.ncbi.nlm.nih.gov/33882940/
Wirth KJ, Scheibenbogen C. Pathophysiology of skeletal muscle
disturbances in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
(ME/CFS). J Transl Med 2021;19(1):162.
https://www.ncbi.nlm.nih.gov/pubmed/27974102
Di Pierro F, Rossi A, Consensi A, Giacomelli C, Bazzichi L.
Role for a water-soluble form of CoQ10 in female subjects affected by
fibromyalgia. A preliminary study. Clin Exp Rheumatol 2017;35 Suppl
105(3):20-27.
https://pubmed.ncbi.nlm.nih.gov/32991532/
Rus A, Robles-Fernandez I, Martinez-Gonzalez LJ, Carmona R,
Alvarez-Cubero MJ. Influence of Oxidative Stress-Related Genes on
Susceptibility to Fibromyalgia. Nurs Res 2021;70(1):44-50.
https://pubmed.ncbi.nlm.nih.gov/33630539/
Aguilar-Ferrándiz ME, Casas-Barragán A, Rus A, Tapia-Haro RM,
Martínez-Martos JM, Molina F, Correa-Rodríguez M. Associations Among
Nitric Oxide and Enkephalinases With Fibromyalgia Symptoms. Nurs Res
2021;70(2):E11-E20.
https://pubmed.ncbi.nlm.nih.gov/18496697/
Sendur OF, Tastaban E, Turan Y, Ulman C. The relationship
between serum trace element levels and clinical parameters in
patients with fibromyalgia. Rheumatol Int
2008;28(11):1117-21.
https://pubmed.ncbi.nlm.nih.gov/28453534/
Joustra ML, Minovic I, Janssens KAM, Bakker SJL, Rosmalen JGM.
Vitamin and mineral status in chronic fatigue syndrome and
fibromyalgia syndrome: A systematic review and meta-analysis. PLoS
One 2017;12(4):e0176631.
https://pubmed.ncbi.nlm.nih.gov/22022174/
Kim YS, Kim KM, Lee DJ, Kim BT, Park SB, Cho DY, Suh CH, Kim
HA, Park RW, Joo NS. Women with fibromyalgia have lower levels of
calcium, magnesium, iron and manganese in hair mineral analysis. J
Korean Med Sci 2011;26(10):1253-7.
https://www.sciencedirect.com/science/article/abs/pii/S0011393X05807738
https://pubmed.ncbi.nlm.nih.gov/19133251/
Cordero MD, Moreno-Fernández AM, deMiguel M, Bonal P, Campa F,
Jiménez-Jiménez LM, Ruiz-Losada A, Sánchez-Domínguez B, Sánchez
Alcázar JA, Salviati L, Navas P. Coenzyme Q10 distribution in blood
is altered in patients with fibromyalgia. Clin Biochem
2009;42(7-8):732-5.
https://pubmed.ncbi.nlm.nih.gov/19133251/
Cordero MD, Moreno-Fernández AM, deMiguel M, Bonal P, Campa F,
Jiménez-Jiménez LM, Ruiz-Losada A, Sánchez-Domínguez B, Sánchez
Alcázar JA, Salviati L, Navas P. Coenzyme Q10 distribution in blood
is altered in patients with fibromyalgia. Clin Biochem
2009;42(7-8):732-5.
https://pubmed.ncbi.nlm.nih.gov/9820664/
Reinhard P, Schweinsberg F, Wernet D, Kötter I. Selenium status
in fibromyalgia. Toxicol Lett 1998;96-97():177-80.
https://pubmed.ncbi.nlm.nih.gov/21347604/
Sakarya ST, Akyol Y, Bedir A, Canturk F. The relationship
between serum antioxidant vitamins, magnesium levels, and clinical
parameters in patients with primary fibromyalgia syndrome. Clin
Rheumatol 2011;30(8):1039-43.
https://pubmed.ncbi.nlm.nih.gov/31387429/
Sawaddiruk P, Apaijai N, Paiboonworachat S, Kaewchur T,
Kasitanon N, Jaiwongkam T, Kerdphoo S, Chattipakorn N, Chattipakorn
SC. Coenzyme Q10 supplementation alleviates pain in
pregabalin-treated fibromyalgia patients
via reducing brain activity and mitochondrial dysfunction.
Free Radic Res 2019;53(8):901-909.
https://pubmed.ncbi.nlm.nih.gov/32922097
Martínez-Lara A, Moreno-Fernández AM, Jiménez-Guerrero M,
Díaz-López C, De-Miguel M, Cotán D, Sánchez-Alcázar JA. Mitochondrial
Imbalance as a New Approach to the Study of Fibromyalgia. Open Access
Rheumatol 2020;12():175-185.
https://pubmed.ncbi.nlm.nih.gov/20109177/
Cordero MD, De Miguel M, Moreno Fernández AM, Carmona López IM,
Garrido Maraver J, Cotán D, Gómez Izquierdo L, Bonal P, Campa F,
Bullon P, Navas P, Sánchez Alcázar JA. Mitochondrial dysfunction and
mitophagy activation in blood mononuclear cells of fibromyalgia
patients: implications in the pathogenesis of the disease. Arthritis
Res Ther 2010;12(1):R17.
https://pubmed.ncbi.nlm.nih.gov/21496502/
Cordero MD, Alcocer-Gómez E, de Miguel M, Cano-García FJ, Luque
CM, Fernández-Riejo P, Fernández AM, Sánchez-Alcazar JA. Coenzyme
Q(10): a novel therapeutic approach for Fibromyalgia? case series
with 5 patients. Mitochondrion 2011;11(4):623-5.
https://pubmed.ncbi.nlm.nih.gov/31150373/
Ferreira I, Ortigoza Á, Moore P. Magnesium and malic acid
supplement for fibromyalgia. Medwave 2019;19(4):e7633.
https://pubmed.ncbi.nlm.nih.gov/34006944/
Yao WC, Chen HJ, Leong KH, Chang KL, Wang YT, Wu LC, Tung PY,
Kuo CF, Lin CC, Tsai SY. The risk of fibromyalgia in patients with
iron deficiency anemia: a nationwide population-based cohort study.
Sci Rep 2021;11(1):10496.
https://pubmed.ncbi.nlm.nih.gov/23554283/
Alves CR, Santiago BM, Lima FR, Otaduy MC, Calich AL, Tritto
AC, de Sá Pinto AL, Roschel H, Leite CC, Benatti FB, Bonfá E, Gualano
B. Creatine supplementation in fibromyalgia: a randomized,
double-blind, placebo-controlled trial. Arthritis Care Res (Hoboken)
2013;65(9):1449-59.
https://pubmed.ncbi.nlm.nih.gov/23834645/
Meeus M, Nijs J, Hermans L, Goubert D, Calders P. The role of
mitochondrial dysfunctions due to oxidative and nitrosative stress in
the chronic pain or chronic fatigue syndromes and fibromyalgia
patients: peripheral and central mechanisms as therapeutic targets?
Expert Opin Ther Targets 2013;17(9):1081-9.
https://pubmed.ncbi.nlm.nih.gov/35831850/
Ghavidel-Parsa B, Naeimi A, Gharibpoor F, Sattari N, Jafari A,
Masooleh IS, Montazeri A. Effect of vitamin B6 on pain, disease
severity, and psychological profile of fibromyalgia patients; a
randomized, double-blinded clinical trial. BMC Musculoskelet Disord
2022;23(1):664.
https://pubmed.ncbi.nlm.nih.gov/23696141/
Costantini A, Pala MI, Tundo S, Matteucci P. High-dose thiamine
improves the symptoms of fibromyalgia. BMJ Case Rep
2013;2013():.
https://pubmed.ncbi.nlm.nih.gov/35566585/
Fernández-Araque A, Verde Z, Torres-Ortega C, Sainz-Gil M,
Velasco-Gonzalez V, González-Bernal JJ, Mielgo-Ayuso J. Effects of
Antioxidants on Pain Perception in Patients with Fibromyalgia-A
Systematic Review. J Clin Med 2022;11(9):.
https://pubmed.ncbi.nlm.nih.gov/31354925/
Proia P, Amato A, Contrò V, Monaco AL, Brusa J, Brighina F,
Messina G. Relevance of lactate level detection in migrane and
fibromyalgia. Eur J Transl Myol 2019;29(2):8202.
https://pubmed.ncbi.nlm.nih.gov/26296670/
de Sá Ribeiro GA, Scola RH, Piovesan EJ, Wollmann Junior DR,
Paiva Edos S, da Cunha CL, Werneck LC. The importance of lactic acid
in migraines and fibromyalgia. Rev Bras Reumatol
2015;55(6):471-6.
https://pubmed.ncbi.nlm.nih.gov/3741498/
Bengtsson A, Henriksson KG, Larsson J. Reduced high-energy
phosphate levels in the painful muscles of patients with primary
fibromyalgia. Arthritis Rheum 1986;29(7):817-21.